The word "user" uses 4 letters: E R S U.
Words formed by adding one letter before or after user (in bold), or to ersu in any order:
a - aures urase ureas ursae b - burse rebus rubes suber c - cruse cures curse ecrus sucre d - druse dures e - reuse g - grues surge urges h - usher i - sieur l - lures rules m - mures muser serum n - nurse runes o - euros roues rouse p - purse sprue super r - ruers surer s - ruses suers users t - trues x - xerus
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